Comics Contiuum has a blurb about how David Chokachi (Jake) sees his character evolving in this second season. It also includes several season 2 photo shoot pics of Jake. It appears they are going with a more messy look for his hair rather than the outdated spike look. And this Jake appears not to be clean-shaven. Edgier perhaps. The new season starts Sunday, June 16th at 8 pm EDT with the 2 episodes, Emergence and Destiny. Otherwise, Witchblade will normally air Monday evenings at 9 pm EDT.
Schnee debriefed at 11:12 AM

As I was on the phone last night, half watching ER, who appears on the TV screen but Nester Serrano (Captain Dante). He plays some sort of government official who arrives on the scene when two children at the hospital present with what appears to be Smallpox. I didn't catch his character's name and exact affiliation. I think the part 2 to this episode is next week and he will likely appear in that episode as well. Additionally I'd like to thank Yarvani for emailing this same intel. ER airs Thursdays on NBC at 10 pm EDT.

[Note added 5/23: I guess that was the season finale. Part 2 is next season, LOL.]
Schnee debriefed at 7:52 AM

From 5/13, Comics Continuum has another interview with Ralph Hemecker, executive producer of Witchblade. In it he gives more vague clues about the next season.

Also, Comics2Film has more remarks from Ralph Hemecker as supplied in the show's presskit in it's 5/14 entry. And a 5/8 entry details the same spoliers given previously by Comics Continuum. The trailer for the season opener can be found on TNT's multimedia site.
Schnee debriefed at 12:19 PM